abstract：:Middle-aged and aged rats received dorsal hippocampal lesions before performance was evaluated on the radial-arm maze. The maze task contained simultaneous spatial working memory and visually cued reference memory components. Both middle-aged and aged rats that received lesions committed more errors of both types than...

journal_title：Neurobiology of aging

authors： Ward MT,Stoelzel CR,Markus EJ

更新日期：1999-07-01 00:00:00

abstract：:The amyloid beta-peptide (A beta)-associated free radical oxidative stress model for neuronal death in Alzheimer's disease (AD) brain predicts that neuronal protein oxidation is a consequence of A beta-associated free radicals [8]. In this study we have used both in vitro and in vivo models of beta-amyloid (A beta) to...

journal_title：Neurobiology of aging

authors： Yatin SM,Varadarajan S,Link CD,Butterfield DA

更新日期：1999-05-01 00:00:00

abstract：:Pertinent animal models of age-related learning deficiencies are required to elucidate the mechanism of age-related learning deficiencies and to develop novel therapeutic drugs for age-related diseases such as learning defects. Among many strains of accelerated senescence prone, senescence-accelerated mouse (SAM), SAM...

journal_title：Neurobiology of aging

authors： Nomura Y,Okuma Y

更新日期：1999-03-01 00:00:00

abstract：:I propose that North American investigators who depend largely on individual external grants would benefit from the creation of regional facilities designed to support studies of aging in transgenic models. In general, academic institutions cannot achieve the most cost effectiveness because their facilities are not de...

journal_title：Neurobiology of aging

authors： Finch CE

更新日期：1999-03-01 00:00:00

abstract：:Neurokinin B and its cognate neurokinin-3 receptor are expressed more in the forebrain than in brain stem structures but little is known about the primary function of this peptide system in the central processing of information. In general, few studies have specifically addressed age-related changes of tachykinins, no...

journal_title：Neurobiology of aging

authors： Mileusnic D,Magnuson DJ,Hejna MJ,Lorens JB,Lorens SA,Lee JM

更新日期：1999-01-01 00:00:00

abstract：:In terminal Alzheimer's disease (AD) the frequency of plaques was found to be reduced in single cases. To test this finding in a larger sample, and in order to determine whether the number of plaques labeled with different markers and the distribution of neurofibrillary tangles are correlated positively to each other ...

journal_title：Neurobiology of aging

authors： Thal DR,Arendt T,Waldmann G,Holzer M,Zedlick D,Rüb U,Schober R

更新日期：1998-11-01 00:00:00

abstract：:A loss of hippocampal neurons and synapses had been considered a hallmark of normal aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent stereological studies in humans have shown that only a relatively minor neuron loss occurs with aging and that this loss is restricted to spe...

journal_title：Neurobiology of aging

authors： Calhoun ME,Kurth D,Phinney AL,Long JM,Hengemihle J,Mouton PR,Ingram DK,Jucker M

更新日期：1998-11-01 00:00:00

abstract：:Dogs exhibit both neuroanatomical and cognitive changes as a function of age that parallel those seen in aging humans. This study describes in vivo changes in neuroanatomical and cerebrovascular characteristics of the canine brain as a function of age in a group of dogs ranging from 4 to 15 years old. Dynamic contrast...

journal_title：Neurobiology of aging

authors： Su MY,Head E,Brooks WM,Wang Z,Muggenburg BA,Adam GE,Sutherland R,Cotman CW,Nalcioglu O

更新日期：1998-09-01 00:00:00

abstract：:Abnormal elevations in ammonia have been implicated in the pathogenesis of Alzheimer's disease. However, the biochemical mechanism(s) leading to increased ammonia in Alzheimer's disease have not yet been identified. A potential source of increased ammonia production is adenosine monophosphate (AMP) deaminase, an impor...

journal_title：Neurobiology of aging

authors： Sims B,Powers RE,Sabina RL,Theibert AB

更新日期：1998-09-01 00:00:00

abstract：:We have shown previously that the TG-3 and MPM-2 antibodies recognize phosphoepitopes common to mitosis and degenerating neurons of Alzheimer's disease(AD) brain. Here, we have evaluated their occurrence in human brain biopsy tissue, and confirm that they are absent in mature neurons of adult brain, but reappear durin...

journal_title：Neurobiology of aging

authors： Vincent I,Zheng JH,Dickson DW,Kress Y,Davies P

更新日期：1998-07-01 00:00:00

abstract：:Calcium-binding proteins play potentially important roles in neurogenesis and neuroprotective mechanism(s). Some evidence exists that brain calbindin-D28K (CALB) is regulated by androgens. In the present study, calretinin (CALRET) and CALB patterns were determined by Western analysis in the medial basal hypothalamus (...

journal_title：Neurobiology of aging

authors： Lephart ED,Taylor H,Jacobson NA,Watson MA

更新日期：1998-05-01 00:00:00

abstract：:The significance of amyloid beta protein, especially those ending at the 42nd residue (Abeta42), in the pathogenesis of familial Alzheimer's disease (FAD) linked to the mutations of presenilins, was examined by transfection studies using cultured cells and immunohistochemical analysis of autopsied brains. The levels o...

journal_title：Neurobiology of aging

authors： Iwatsubo T

更新日期：1998-01-01 00:00:00

abstract：:Carboxyl-terminal fragments of beta amyloid precursor protein (betaAPP) were expressed in mice under the transcriptional control of an ubiquitous promoter system, based upon a chicken beta-actin (betaA) promoter combined with cytomegalovirus (CMV) enhancer to obtain a systemic overproduction of amyloid beta protein (A...

journal_title：Neurobiology of aging

authors： Shoji M,Kawarabayashi T,Sato M,Sasaki A,Matsubara E,Igeta Y,Kanai M,Tomidokoro Y,Shizuka M,Ishiguro K,Harigaya Y,Okamoto K,Hirai S

更新日期：1998-01-01 00:00:00

abstract：:Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to ...

journal_title：Neurobiology of aging

authors： Markesbery WR,Lovell MA

更新日期：1998-01-01 00:00:00

abstract：:Astrocytes and microglia from cerebral cortex of 3-, 6-, 12-, and 24-month-old F344 male rat donors showed progressively greater proliferation during primary culture. Microglia from aging donor brains exhibited an amoeboid-like morphology and express antigens characteristic of an activated state (e.g., major histocomp...

journal_title：Neurobiology of aging

authors： Rozovsky I,Finch CE,Morgan TE

更新日期：1998-01-01 00:00:00

abstract：:The effects of age were studied on a new animal model of tardive dyskinesia, i.e., the quantification of oral dyskinesia in rats repeatedly treated with reserpine. Adult and old rats received two injections of reserpine (0.5 or 1.0 mg/kg s.c.) or vehicle, separated by 48 h. One, 10, 25 and 40 days after the second inj...

journal_title：Neurobiology of aging

authors： Bergamo M,Abílio VC,Queiroz CM,Barbosa-Júnior HN,Abdanur LR,Frussa-Filho R

更新日期：1997-11-01 00:00:00

abstract：:4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD), we quantified levels of free and protein-b...

journal_title：Neurobiology of aging

authors： Lovell MA,Ehmann WD,Mattson MP,Markesbery WR

更新日期：1997-09-01 00:00:00

abstract：:Aged, cognitively-impaired rats (and humans) show hypothalamic-pituitary-adrenal (HPA) hyperactivity that correlates with hippocampal damage. The resultant increase in plasma glucocorticoid exposure is thought to contribute to impaired hippocampal function and to potentiate hippocampal neuron death. In young, adult ra...

journal_title：Neurobiology of aging

authors： Rowe W,Steverman A,Walker M,Sharma S,Barden N,Seckl JR,Meaney MJ

更新日期：1997-09-01 00:00:00

abstract：:The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up. The individuals (n = 20, age from 49-98 years) included in this study were carefully examined for absence of neurologica...

journal_title：Neurobiology of aging

authors： Ohm TG,Busch C,Bohl J

更新日期：1997-07-01 00:00:00

abstract：:The definitive diagnosis of Alzheimer's disease (AD) is made at autopsy by the presence of abundant neuritic plaques (NP) and neurofibrillary tangles (NFT) in the neocortex, entorhinal cortex, and hippocampus. The two criteria most frequently used by neuropathologists for the diagnosis of AD over the past 12 years are...

journal_title：Neurobiology of aging

authors： Markesbery WR

更新日期：1997-07-01 00:00:00

abstract：:Despite recognition that Alzheimer's disease (AD) is a polygenic and heterogeneous dementing neurodegenerative disorder, there is continued merit in defining the AD phenotype by the presence of progressive cognitive impairments and the pathological brain lesions (senile plaques, neurofibrillary tangles) as originally ...

journal_title：Neurobiology of aging

authors： Trojanowski JQ,Clark CM,Schmidt ML,Arnold SE,Lee VM

更新日期：1997-07-01 00:00:00

abstract：:The relationship between the neurofibrillary tangles and the intellectual deficit observed in senile dementia of the Alzheimer type was studied in 27 patients over the age of 75. The presence and density of tau positive tangles were assessed in six areas including limbic, paralimbic, and isocortical cortices. In the i...

journal_title：Neurobiology of aging

authors： Duyckaerts C,Bennecib M,Grignon Y,Uchihara T,He Y,Piette F,Hauw JJ

更新日期：1997-05-01 00:00:00

abstract：:Although important in neurodegeneration, systematic studies of nicotinic acetylcholine receptor expression in normal aging human brains are difficult to perform. We have studied the expression of nicotinic receptor alpha 4-1 and alpha 5 mRNA in the frontal and parietal isocortex of 3- (young adult), 24- (late middle a...

journal_title：Neurobiology of aging

authors： Birtsch C,Wevers A,Traber J,Maelicke A,Bloch W,Schröder H

更新日期：1997-05-01 00:00:00

abstract：:While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28...

journal_title：Neurobiology of aging

authors： Gearing M,Tigges J,Mori H,Mirra SS

更新日期：1997-03-01 00:00:00

abstract：:We have previously shown beneficial effects of a Ginkgo biloba extract (EGb761-IPSEN) in accelerating functional recovery from hemiplegia induced by unilateral motor cortex ablation. Here, we report the behavioral and histological effects of various dose regimes of EGb761. In young rats (3 months), 10 mg/kg/day for 7 ...

journal_title：Neurobiology of aging

authors： Brailowsky S,Montiel T

更新日期：1997-03-01 00:00:00

abstract：:The brains of 14 rhesus monkeys (Macaca mulatta) between 4 and 35 years old were examined to determine the effects of aging on the thickness, neuronal frequency, fine structure, surface area, and volume of striate cortex. The effects of aging were ascertained by comparing the striate cortex in the six monkeys between ...

journal_title：Neurobiology of aging

authors： Peters A,Nigro NJ,McNally KJ

更新日期：1997-01-01 00:00:00

abstract：:We investigated the effect of apolipoprotein E (apoE) genotype on amyloid load in the frontal and cerebellar cortices of 24 patients with definite Alzheimer disease (AD) and 19 controls. Amyloid load was examined by using two methods: 1) acid-extractable amyloid beta-protein (A beta) and insoluble A beta levels of fro...

journal_title：Neurobiology of aging

authors： Pirttilä T,Soininen H,Mehta PD,Heinonen O,Lehtimäki T,Bogdanovic N,Paljärvi L,Kim KS,Kosunen O,Winblad B,Riekkinen P Sr,Wisniewski HM

更新日期：1997-01-01 00:00:00

abstract：:There is a marked increase with advancing age of stimulation-evoked neurotransmitter release from vascular adrenergic nerves in the rat, an effect correlated with increased levels of plasma norepinephrine. This increase in norepinephrine release could not be accounted for by an alteration in neuronal and extraneuronal...

journal_title：Neurobiology of aging

authors： Buchholz J,Tsai H,Foucart S,Duckles SP

更新日期：1996-11-01 00:00:00

abstract：:Appreciation of the role that inflammatory mediators play in Alzheimer's disease (AD) pathogenesis continues to be hampered by two related misconceptions. The first is that to be pathogenically significant a neurodegenerative mechanism must be primary. The second is that inflammation merely occurs to clear the detriti...

journal_title：Neurobiology of aging

authors： Rogers J,Webster S,Lue LF,Brachova L,Civin WH,Emmerling M,Shivers B,Walker D,McGeer P

更新日期：1996-09-01 00:00:00

abstract：:Activated astrocytes have been identified as the main source of the serine protease inhibitor alpha 1-antichymotrypsin (ACT), an acute phase protein that is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. We analyzed the synthesis of ACT by cultured murine...

journal_title：Neurobiology of aging

authors： Kanemaru K,Meckelein B,Marshall DC,Sipe JD,Abraham CR

更新日期：1996-09-01 00:00:00

abstract：:Age-related changes in resting levels of the free intracellular calcium concentration ([Ca2+]i) as well as alterations of the rise in [Ca2+]i following depolarization have been investigated in acutely isolated brain cells of various regions of the rat brain. Characterization of the Ca2+ responses following KCl depolar...

journal_title：Neurobiology of aging

authors： Hartmann H,Velbinger K,Eckert A,Müller WE

更新日期：1996-07-01 00:00:00

abstract：:Recent reports have suggested that beta-amyloid (A beta) species of variable length C-termini are differentially deposited within early and late-stage plaques and the cerebrovasculature. Specifically, longer C-terminal length A beta 42/3 fragments (i.e., A beta forms extending to residues 42 and/or 43) are thought to ...

journal_title：Neurobiology of aging

authors： Cummings BJ,Satou T,Head E,Milgram NW,Cole GM,Savage MJ,Podlisny MB,Selkoe DJ,Siman R,Greenberg BD,Cotman CW

更新日期：1996-07-01 00:00:00

abstract：:Detailed analyses of neuronal and astrocyte cell numbers in the ganglion cell layer (GCL) of whole-mounted peripheral retinas from 16 Alzheimer's disease (AD) and 11 control eyes (11 and 9 cases, respectively) demonstrate extensive neuronal loss throughout the entire retina in AD as compared to control eyes. The obser...

journal_title：Neurobiology of aging

authors： Blanks JC,Schmidt SY,Torigoe Y,Porrello KV,Hinton DR,Blanks RH

更新日期：1996-05-01 00:00:00

abstract：:The classic hallmarks of Alzheimer's disease are the deposition of amyloid in plaques and in the cerebrovasculature, and the emergence of neurofibrillary tangles in neurons. The interplay between these two pathologic processes, on the one hand, and the degeneration of neurons and loss of cognitive functions on the oth...

journal_title：Neurobiology of aging

authors： Neve RL,Boyce FM,McPhie DL,Greenan J,Oster-Granite ML

更新日期：1996-03-01 00:00:00

abstract：:Eyeblink classical conditioning (EBCC) is impared in rabbits and humans during normal aging and severely disrupted in Alzheimer's disease (AD) and older Down's Syndrome patients (called DS/AD). To determine if older rabbit brains developed neuropathological evidence of Alzheimer-like pathology to account for impaired ...

journal_title：Neurobiology of aging

authors： Woodruff-Pak DS,Trojanowski JQ

更新日期：1996-03-01 00:00:00

abstract：:In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

journal_title：Neurobiology of aging

authors： Roman FS,Alescio-Lautier B,Soumireu-Mourat B

更新日期：1996-01-01 00:00:00

abstract：:A group of 51 healthy elderly volunteer subjects participated in a 3- to 6-year longitudinal study of basal cortisol levels. Once per year basal cortisol levels were examined using hourly sampling over a 24-h period. Analyses of three cortisol measures (last measure obtained, mean cortisol levels across years, and the...

journal_title：Neurobiology of aging

authors： Lupien S,Lecours AR,Schwartz G,Sharma S,Hauger RL,Meaney MJ,Nair NP

更新日期：1996-01-01 00:00:00

abstract：:The levels of calpains (m-calpain and mu-calpain) in peripheral blood lymphocytes from patients with Alzheimer's disease were determined via Western blotting. The Ca-dependent proteolytic activity and the calpastatin activity were estimated using incubation with exogenous substrate. Evidence was obtained for an increa...

journal_title：Neurobiology of aging

authors： Karlsson JO,Blennow K,Janson I,Blomgren K,Karlsson I,Regland B,Wallin A,Gottfries CG

更新日期：1995-11-01 00:00:00

abstract：:In the aging mammalian hypothalamus, a unique subpopulation of glial cells accumulates peroxidase-positive cytoplasmic inclusions distinct from lipofuscin. In adult rodents, this senescence-dependent glial granulation is accelerated by administration of estradiol valerate. In the present study, brain sections derived ...

journal_title：Neurobiology of aging

authors： Mydlarski MB,Liberman A,Schipper HM

更新日期：1995-11-01 00:00:00

abstract：:An age-related increase in stimulation-evoked fractional norepinephrine release has been demonstrated in tail artery of Fischer-344 rats from 6 to 20 months of age. Previous studies have ruled out alterations in function of uptake mechanisms, metabolism, or feedback via prejunctional alpha-2 adrenoceptors, suggesting ...

journal_title：Neurobiology of aging

authors： Tsai H,Duckles SP,Buchholz J

更新日期：1995-09-01 00:00:00